Figure 4.

Drug (Sodium demethylcantharidate) significantly decrease the tumorigenicity of SMMC-7721 cells in a nude mouse xenograft model. A. The dissected tumors from each group of mice 16 days after inoculation with SMMC-7721 cells. B. Drug induced ER stress in dissected tumors of the xenograft model. C. Mass of the dissected tumors for the two groups. Each histogram represents mean ± SD of six mice. D. Tumor volumes were measured every two days. E. Body weight of nude mice were measured every two days. There were no obvious change between the two group, indicating the decrease of tumor mass and volume were not caused by a loss of body weight. Data are represented as means ± SD. *P<0.05 vs. control.