Figure 6.
Effect of Ginsenoside Rb1 on production of Aβ1-42 by enzyme-linked immunusorbent assay) and on long Aβ cleavage by LC-MS/MS. Hippocampal tissue secreted amyloid protein 1-42 levels were measured by ELISA in the five groups of NG, CG, AG, RG and MG (A). Relative IAT, VIV, and ITL levels in cell lysates during Aβ1-42 formation (B). Relative VVIA, TVI, and VIT levels in cell lysates during Aβ1-42 formation (C). Results are expressed as a ratio of NG. Data are expressed as mean ± SD, and analyzed by one-way analysis of variance. *P < 0.05, **P < 0.01, vs. NG. LC-MS/MS: liquid chromatography-tandem mass spectrometer. NG: normal group; CG: control group; AG: AD model group; RG: Aricept group; MG: mid-dose ginsenoside Rb1 group.