Figure 1.

FOXO1 is downregulated and predicts poor patient prognosis in patients with PDAC. A: FOXO1 mRNA levels as detected by RT-qPCR in fresh PDAC tissues and normal tissues (n = 57). B: FOXO1 protein levels as detected by western blotting in three paired clinical normal and PDAC tissues. C: mRNA and protein levels of FOXO1 in the normal pancreatic ductal epithelial cell HPNE and in the indicated PDAC cell lines. D: IHC staining revealing FOXO1 protein expression in PDAC and adjacent tumor tissues of patients (scale bar, 50 µm). E: Patients with low FOXO1 expression have poor survival probability.