Skip to main content
. 2019 May 15;11(5):2801–2815.

Figure 7.

Figure 7

RMRP/miR-613 axis promotes the tumorigenesis of HCC. A. The transfected Hep3B cells were subcutaneously injected into the left flanks of male athymic Balb/c nude mice and HCC tumorigenesis was measured. The tumor size was monitored every five days. The growth curves generated for tumor volume in the nude mice demonstrated that knockdown of RMRP significantly inhibited tumor growth in vivo. B. Co-transfected with siRNA-RMRP and miR-613 inhibitor increased tumor growth compared to cells treated with siRNA-RMRP and inhibitor control. C. Knockdown RMRP decreased tumor size, while miR-613 silencing could partly reversed the inhibitory effect of RMRP knockdown. D. The tumors were isolated and weighed after 35 days. RMRP knockdown decreased tumor weight, and tumor weight in siRNA-RMRP and miR-613 inhibitor group was increased compared to siRNA-RMRP and inhibitor control group. E. The expression of RMRP and miR-613 in xenograft from the nude mice was determined by qRT-PCR assay. The experiments were performed in triplicate. **P < 0.01.