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. 2019 May 15;11(5):3048–3055.

Figure 2.

Figure 2

Expression of Bcl2L12 by CD4+ T cells negatively correlates with peripheral Tregs in RA patients. CD4+ T cells were isolated from PBMCs by MACS. Total RNA and proteins were extracted from the cells and analyzed by RT-qPCR and Western blotting. (A) Foxp3 mRNA levels in CD4+ T cells. (B) Foxp3 protein levels in CD4+ T cells. (C) Bcl2L12 mRNA levels in isolated CD4+ T cells. (D) Bcl2L12 protein levels in isolated CD4+ T cells. Protein extracts of 20 RA patients and HA subjects were pooled, respectively. Data of (B and D) are from one experiment represent 3 independent experiments. (E) Negative correlation between Bcl2L12 mRNA and Foxp3 mRNA in CD4+ T cells of RA patients.