Figure 5.

Bcl2L12 interferes with Treg generation. Naive CD4⁺ T cells were isolated from PBMCs collected from HA subjects and RA patients. The cells were treated with Treg generation condition (Treg gener-condi) and the procedures denoted above each dot plot panel. (A) The gated dot plots show frequency of generated Treg. (B) The bars show summarized data of generated Tregs in (A). (C) Results of Bcl2L12 RNAi. RNAi (cRNAi): RA CD4⁺ T cells were treated with Bcl2L12 RNAi) or control RNAi). The data represent 3 independent experiments.