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Sitagliptin suppresses advanced glycation end-products (AGEs)-induced degradation of aggrecan in human primary chondrocytes (HPCs). HPCs were treated with 100 μg/ml AGEs in the presence or absence of 100, 200 nM sitagliptin for 48 h. Expression of aggrecan was determined by western blot analysis (a, b, c, P<0.01 vs. previous column group).
