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Sitagliptin inhibits the activation of the NF-κB signaling. Human primary chondrocytes (HPCs) were treated with 100 μg/ml AGEs in the presence or absence of 100, 200 nM sitagliptin for 48 h. A. Nuclear translocation of NF-κB p65; B. NF-κB luciferase activity (a, b, c, P<0.01 vs. previous column group).
