Table 1.
Characteristics of malignant pleural mesothelioma cases in the National Cancer Database (NCDB) according to gender
| Propensity-matched sample | ||||||
|---|---|---|---|---|---|---|
| Variable | Males (n = 12 800) No. (%) |
Females (n = 3467) No. (%) |
P a | Males (n = 2374) No. (%) |
Females (n = 2374) No. (%) |
P a |
| Age (years) | <0.0001 | 0.9877 | ||||
| <50 | 261 (2.0) | 176 (5.1) | 76 (3.2) | 84 (3.5) | ||
| 50–59 | 1013 (7.9) | 422 (12.2) | 286 (12.0) | 283 (11.9) | ||
| 60–69 | 3115 (24.3) | 747 (21.5) | 519 (21.9) | 510 (21.5) | ||
| 70–79 | 4669 (36.5) | 1086 (31.3) | 754 (31.8) | 748 (31.5) | ||
| ≥80 | 3742 (29.2) | 1036 (29.9) | 739 (31.1) | 749 (31.6) | ||
| Race | 0.1665 | 0.4704 | ||||
| White | 11 909 (93.0) | 3200 (92.3) | 2187 (92.1) | 2198 (92.6) | ||
| Black | 561 (4.4) | 158 (4.6) | 116 (4.9) | 113 (4.8) | ||
| Asian/other | 330 (2.6) | 109 (3.1) | 71 (3.0) | 63 (2.7) | ||
| Spanish/Hispanic origin | 0.0748 | 0.6362 | ||||
| No | 11 416 (89.2) | 3064 (88.4) | 2252 (94.9) | 2259 (95.2) | ||
| Yes | 495 (3.9) | 157 (4.5) | 122 (5.1) | 115 (4.8) | ||
| Missing/unknown | 889 (6.9) | 246 (7.1) | ||||
| % of adults in patient zip code without a HS degree (quartiles) | 0.0089 | 0.8237 | ||||
| ≥21 | 1631 (12.7) | 449 (13.0) | 331 (13.9) | 321 (13.5) | ||
| 13–20.9 | 3065 (23.9) | 841 (24.3) | 580 (24.4) | 581 (24.5) | ||
| 7–12.9 | 4576 (35.8) | 1145 (33.0) | 805 (33.9) | 818 (34.5) | ||
| <7 | 3153 (24.6) | 933 (26.9) | 658 (27.7) | 654 (27.5) | ||
| Missing/unknown | 375 (2.9) | 99 (2.9) | ||||
| Patient zip code median income ($) (quartiles) | 0.0353 | 0.4103 | ||||
| <38 000 | 1704 (13.3) | 462 (13.3) | 327 (13.8) | 304 (12.8) | ||
| 38 000–47 999 | 2925 (22.9) | 735 (21.2) | 513 (21.6) | 501 (21.1) | ||
| 48 000–62 999 | 3595 (28.1) | 950 (27.4) | 652 (27.5) | 688 (29.0) | ||
| ≥63 000 | 4197 (32.8) | 1221 (35.2) | 882 (37.2) | 881 (37.1) | ||
| Missing/unknown | 379 (3.0) | 99 (2.9) | ||||
| Insurance | <0.0001 | 0.7976 | ||||
| Uninsured | 221 (1.7) | 70 (2.0) | 40 (1.7) | 46 (1.9) | ||
| Private insurance | 2947 (23.0) | 931 (26.9) | 653 (27.5) | 648 (27.3) | ||
| Medicaid | 246 (1.9) | 113 (3.3) | 77 (3.2) | 84 (3.5) | ||
| Medicare/other government | 9033 (70.6) | 2265 (65.3) | 1604 (67.6) | 1596 (67.2) | ||
| Missing/unknown | 353 (2.8) | 88 (2.5) | ||||
| Charlson Comorbidity Index | 0.0020 | 0.2013 | ||||
| 0 | 8647 (67.6) | 2443 (70.5) | 1729 (72.8) | 1678 (70.7) | ||
| 1 | 2972 (23.2) | 755 (21.8) | 468 (19.7) | 518 (21.8) | ||
| ≥2 | 1181 (9.2) | 269 (7.8) | 177 (7.5) | 178 (7.5) | ||
| Facility type | 0.2436 | 0.5090 | ||||
| Community Cancer Program | 7384 (57.7) | 1944 (56.1) | 1390 (58.6) | 1368 (57.6) | ||
| Academic/Integrated Network | 5354 (41.8) | 1475 (42.5) | 984 (41.4) | 1006 (42.4) | ||
| Missing/unknown | 62 (0.5) | 48 (1.4) | ||||
| Distance from patient to reporting facility (miles) | 0.0117 | 0.9645 | ||||
| <25 | 9209 (71.9) | 2577 (74.3) | 1845 (77.7) | 1843 (77.6) | ||
| 25–49.9 | 1483 (11.6) | 383 (11.0) | 265 (11.2) | 267 (11.2) | ||
| ≥50 | 1741 (13.6) | 412 (11.9) | 264 (11.1) | 264 (11.1) | ||
| Missing/unknown | 367 (2.9) | 95 (2.7) | ||||
| Histology | <0.0001 | 0.3631 | ||||
| Epithelial | 4486 (35.0) | 1396 (40.3) | 979 (41.2) | 948 (39.9) | ||
| Sarcomatoid | 1766 (13.8) | 259 (7.5) | 169 (7.1) | 180 (7.6) | ||
| Biphasic | 996 (7.8) | 194 (5.6) | 153 (6.4) | 138 (5.8) | ||
| Not otherwise specified | 5552 (43.4) | 1618 (46.7) | 1073 (45.2) | 1108 (46.7) | ||
| Laterality | 0.6770 | 0.6976 | ||||
| One side | 11 857 (92.6) | 3163 (91.2) | 2320 (97.7) | 2316 (97.6) | ||
| Bilateral involvement/midline | 320 (2.5) | 81 (2.3) | 54 (2.3) | 58 (2.4) | ||
| Missing/unknown | 623 (4.9) | 223 (6.4) | ||||
| Stage | 0.1360 | 0.7998 | ||||
| Local | 5664 (44.3) | 1475 (42.5) | 1031 (43.4) | 1022 (43.0) | ||
| Regional | 2048 (16.0) | 579 (16.7) | 402 (16.9) | 406 (17.1) | ||
| Distant | 1923 (15.0) | 551 (15.9) | 359 (15.1) | 357 (15.0) | ||
| Missing/unknown | 3165 (24.7) | 862 (24.9) | 582 (24.5) | 589 (24.8) | ||
| Surgery | 0.2129 | 0.7835 | ||||
| No | 10 427 (81.5) | 2861 (82.5) | 1970 (83.0) | 1977 (83.3) | ||
| Yes | 2336 (18.3) | ≥10b | 404 (17.0) | 397 (16.7) | ||
| Missing/unknown | 37 (0.3) | <10b | ||||
| Radiotherapy | 0.3115 | 0.8175 | ||||
| No | 12 044 (94.1) | 3243 (93.5) | 2287 (96.3) | 2284 (96.2) | ||
| Yes | 432 (3.4) | 129 (3.7) | 87 (3.7) | 90 (3.8) | ||
| Missing/unknown | 324 (2.5) | 95 (2.7) | ||||
| Chemotherapy | 0.0004 | 0.9269 | ||||
| No | 6098 (47.6) | 1767 (51.0) | 1277 (53.8) | 1780 (53.9) | ||
| Yes | 6309 (49.3) | 1592 (45.9) | 1097 (46.2) | 1094 (46.1) | ||
| Missing/unknown | 393 (3.1) | 108 (3.1) |
HS, high school.
a
χ2 test among non-missing values.
b
Cells masked to protect against identification of patients.