Table 1.

Associations between SNPs in the AURORA pathway and pancreatic cancer risk with FDR <0.20

SNP	Gene	Chr	Allelea	Position (hg19)	I 2	EAFb	OR (95% CI)c	P c	FDR
rs10820603	SMC2	9	A/G	106877939	0	0.44	1.12 (1.07–1.18)	8.39E-07	0.003
rs7872034	SMC2	9	A/G	106896809	0	0.44	1.12 (1.07–1.17)	9.97E-07	0.003
rs3818626	SMC2	9	T/C	106856633	0	0.44	1.12 (1.07–1.17)	2.20E-06	0.003
rs4743687	SMC2	9	T/C	106856910	0	0.44	1.12 (1.07–1.17)	1.97E-06	0.003
rs4742906	SMC2	9	G/A	106857078	0	0.44	1.12 (1.07–1.17)	1.33E-06	0.003
rs7028408	SMC2	9	A/G	106859811	0	0.44	1.12 (1.07–1.17)	2.12E-06	0.003
rs4742901	SMC2	9	T/C	106856043	8.87	0.29	1.10 (1.04–1.15)	2.92E-04	0.149
rs79447092	ARHGEF7	13	T/A	111809308	0	0.03	0.76 (0.66–0.88)	1.46E-04	0.108
rs17884306	TP53	17	C/T	7572101	0	0.06	0.82 (0.74–0.91)	1.45E-04	0.108
rs9891744	TP53	17	C/T	7574864	0	0.06	0.81 (0.73–0.90)	1.26E-04	0.108
rs9895829	TP53	17	A/G	7578679	0	0.06	0.82 (0.74–0.91)	1.51E-04	0.108
rs17883323	TP53	17	G/T	7579619	0	0.06	0.82 (0.74–0.91)	1.77E-04	0.111
rs8079544	TP53	17	C/T	7580052	0	0.06	0.82 (0.74–0.91)	1.86E-04	0.111
rs75732100	TP53	17	C/T	7576348	0	0.06	0.82 (0.74–0.91)	2.29E-04	0.126
rs17879377	TP53	17	C/T	7574721	0	0.05	0.82 (0.73–0.91)	3.28E-04	0.157

Chr, chromosome; EAF, effect allele frequency; FDR, false discovery rate.

^aReference allele/effect allele.

^bEAF in the controls of three studies (PanScan I, PanScan II/III and PanC4).

^cMeta-analysis of the three studies: Fixed effect models were used when no heterogeneity was found between studies (Q test P > 0.10 and I2 < 50.0%); otherwise, random effect models were used.