Table 2.
Associations between the top three representative SNPs and pancreatic cancer risk in the combined data set of PanScan and PanC4 studies
| Genotype | PanScan + PanC4 | OR (95% CI)a | P a | ||
|---|---|---|---|---|---|
| Case (%) | Control (%) | ||||
| rs3818626 T>C | |||||
| TT | 2402 (28.4) | 2182 (31.5) | 1.00 | ||
| TC | 4247 (50.2) | 3427 (49.4) | 1.13 (1.05–1.21) | 0.001 | |
| CC | 1808 (21.4) | 1323 (19.1) | 1.24 (1.13–1.36) | <0.001 | |
| Trend test | <0.001 | ||||
| Dominant model | |||||
| TT | 2402 (28.4) | 2182 (31.5) | 1.00 | ||
| TC+CC | 6055 (71.6) | 4750 (68.5) | 1.16 (1.08–1.24) | <0.001 | |
| rs79447092 T>A | |||||
| TT | 7944 (95.2) | 6421 (94.0) | 1.00 | ||
| TA | 394 (4.7) | 395 (5.8) | 0.80 (0.69–0.93) | 0.003 | |
| AA | 4 (0.1) | 12 (0.2) | 0.29 (0.09–0.90) | 0.032 | |
| Trend test | <0.001 | ||||
| Dominant model | |||||
| TT | 7944 (95.2) | 6421 (94.0) | 1.00 | ||
| TA+AA | 398 (4.8) | 407 (6.0) | 0.79 (0.68–0.91) | 0.001 | |
| rs9895829 A>G | |||||
| AA | 7675 (90.6) | 6153 (88.6) | 1.00 | ||
| AG | 775 (9.2) | 769 (11.1) | 0.81 (0.73–0.90) | <0.001 | |
| GG | 17 (0.2) | 20 (0.3) | 0.62 (0.32–1.19) | 0.149 | |
| Trend test | <0.001 | ||||
| Dominant model | |||||
| AA | 7675 (90.6) | 6153 (88.6) | 1.00 | ||
| AG+GG | 792 (9.4) | 789 (11.4) | 0.81 (0.73–0.90) | <0.001 |
aAdjusted for age, sex and data source.