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. 2019 Feb 22;40(4):521–528. doi: 10.1093/carcin/bgz029

Table 3.

Associations between number of protective genotypes (NPGs) and risk of pancreatic cancera

NPGb PanScan + PanC4 OR (95% CI)c P c
Case (%) Control (%)
0 5137 (61.8) 3900 (57.3) 1.00
1 2827 (34.0) 2505 (36.8) 0.86 (0.80–0.92) <0.001
2 342 (4.1) 397 (5.8) 0.66 (0.56–0.76) <0.001
3 7 (0.1) 8 (0.1) 0.78 (0.28–2.16) 0.634
Trend test <0.001
0 5137 (61.8) 3900 (57.3) 1.00
1–3 3176 (38.2) 2910 (42.7) 0.83 (0.78–0.88) <0.001

NPG, number of protective genotypes.

aThe logistic regression analysis was performed in the combined data set of PanScan and PanC4 studies.

bProtective genotypes were rs3818626 TT, rs79447092 TA+AA and rs9895829 AG+GG.

cLogistic regression analyses with adjustment for age, sex and data source.