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. 2019 Jun 3;14(6):862–872. doi: 10.2215/CJN.13391118

Figure 2.

Figure 2.

The associations between changes in eGFR and UACR and subsequent risk of major clinical outcomes were similar when changes in these two markers were assessed as continuous variables. 2-Year changes in eGFR and UACR were both strongly associated with future risks of major clinical outcomes. Models were adjusted for age, sex, region of residence, duration of diabetes, history of macrovascular disease, smoking habit, drinking habit, body mass index, HbA1c, total cholesterol, log-transformed triglycerides, eGFR, systolic BP, log-transformed UACR at registration, 2-year change in systolic BP, randomized BP-lowering intervention, and randomized glucose control intervention plus (for change in eGFR only) 2-year change in UACR or (for change in UACR only) 2-year change in eGFR. The circles represent the points at which knots were placed (−40%, −30%, 0%, 30%, and 40%). The gray areas represent the 95% CIs. Values were trimmed at >100% change (0.16% and 3.0% of the participants for change in eGFR and change in UACR, respectively). The red lines represent the HRs of one.