A combination of changes in eGFR and UACR was more strongly associated with subsequent risk of the outcomes than either change alone. Models were adjusted for age, sex, region of residence, duration of diabetes, history of macrovascular disease, smoking habit, drinking habit, body mass index, HbA1c, total cholesterol, log-transformed triglycerides, eGFR, systolic BP, log-transformed UACR at registration, change in systolic BP, randomized BP-lowering intervention, and randomized glucose control intervention.