Table 2.
Discrimination and reclassification statistics (95% CIs) for 8-year risk of the primary outcome after addition of changes in eGFR or UACR to a model containing clinical risk factors
| Model | Δc-Statistic | Integrated Discrimination Improvement | Relative Integrated Discrimination Improvement, % | Net Reclassification Improvement | |
|---|---|---|---|---|---|
| Continuous | Categoricala | ||||
| Base model (reference)b | 0.6602 (0.6478 to 0.6726) | ||||
| Base model plus change in eGFR | 0.0041 (0.0010 to 0.0073) | 0.0046 (0.0036 to 0.0058) | 5.39 (4.11 to 6.80) | 0.114 (0.059 to 0.166) | 0.014 (0.0007 to 0.027) |
| P=0.009 | P<0.001 | P<0.001 | P=0.04 | ||
| Base model plus change in UACR | 0.0054 (0.0022 to 0.0086) | 0.0050 (0.0038 to 0.0062) | 5.85 (4.40 to 7.31) | 0.170 (0.116 to 0.224) | 0.0005 (−0.014 to 0.014) |
| P=0.001 | P<0.001 | P<0.001 | P=0.18 | ||
| Base model plus change in eGFR and UACR and interaction term | 0.0088 (0.0044 to 0.0131) | 0.0096 (0.0080 to 0.0114) | 11.21 (9.25 to 13.34) | 0.168 (0.112 to 0.219) | 0.017 (0.0003 to 0.033) |
| P<0.001 | P<0.001 | P<0.001 | P=0.05 | ||
| Base model plus change in eGFR (reference) | 0.6643 (0.6519 to 0.6768) | ||||
| Addition of change in UACR and interaction term | 0.0046 (0.0016 to 0.0077) | 0.0050 (0.0038 to 0.0062) | 5.55 (4.18 to 6.88) | 0.175 (0.121 to 0.226) | 0.002 (−0.011 to 0.015) |
| P=0.003 | P<0.001 | P<0.001 | P=0.56 | ||
| Base model plus change in UACR (reference) | 0.6656 (0.6533 to 0.6780) | ||||
| Addition of change in eGFR and interaction term | 0.0034 (0.0004 to 0.0063) | 0.0046 (0.0035 to 0.0058) | 5.08 (3.85 to 6.39) | 0.107 (0.051 to 0.159) | 0.017 (0.004 to 0.029) |
| P=0.03 | P<0.001 | P<0.001 | P=0.006 | ||
Change in UACR was log-transformed before the analyses. 95% CI, 95% confidence interval; UACR, urine albumin-to-creatinine ratio.
a
Using cut-off points of 10% and 20% 8-year risk.
b
Base model included age, sex, region of residence, duration of diabetes, history of macrovascular disease, smoking habit, drinking habit, body mass index, hemoglobin A1c, total cholesterol, log-transformed triglycerides, eGFR, systolic BP, log-transformed UACR at registration, 2-year change in systolic BP, randomized BP-lowering intervention, and randomized glucose control intervention.