Serial MR images of the right kidney from patients with PKD1 and PKD2 over 12 follow-up visits illustrate differences and changes in cyst volume and number. (A) Kidney cysts in PKD1 are more numerous and diffusely distributed than (B) those in PKD2. (A) The PKD1 participant was a male aged 15 years at baseline, with a truncating mutation and MSG1, a baseline total kidney volume of 499 ml, total cyst volume of 35 ml, and total cyst number of 456. (B) The PKD2 participant was a male aged 23 years at baseline, with a total kidney volume of 369 ml, total cyst volume of 17 mL, and total cyst number of 68.