Table 1.
Cohort characteristics at baseline
| Characteristics | CRISP Cohort, n=236 | PKD1 Participants, n=188 | PKD2 or NMD Participants, n=48 |
|---|---|---|---|
| Sex, n (%) | |||
| Male | 95 (40) | 73 (39) | 22 (46) |
| Female | 141 (60) | 115 (61) | 26 (54) |
| Irazabal class, n (%) | |||
| Class 1A | 14 (6) | 6 (3) | 8 (17) |
| Class 1B | 59 (25) | 35 (19) | 24 (50) |
| Class 1C | 71 (30) | 58 (31) | 13 (27) |
| Class 1D | 55 (23) | 53 (28) | 2 (4) |
| Class 1E | 37 (16) | 36 (19) | 1 (2) |
| Age, yra | 32 (9) | 32 (9) | 35 (9) |
| Baseline htTKV, ml/ma | 503 (350–757) | 580 (384–890) | 386 (269–449) |
| Genotype, n (%) | |||
| PKD1 truncating | 126 (53) | ||
| PKD1 nontruncating | 62 (26) | ||
| PKD2 or NMD | 48 (20) | ||
| Mutation strength groups, n (%) | |||
| PKD1, MSG1 or MSG2 | 165 (70) | ||
| PKD1, MSG3 | 23 (10) | ||
| PKD2 or NMD | 48 (20) |
CRISP, Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease; PKD, polycystic kidney disease; NMD, no mutation detected; htTKV, height-adjusted total kidney volume; MSG, mutation strength group.
a
Age is summarized as mean (SD); htTKV is summarized at median (interquartile range).