Table 5.

Linear mixed model with interactions for slope in log height-adjusted total cyst number

Category	Model 1			Model 2			Model 3
	Coef.	95% CI	P Value	Coef.	95% CI	P Value	Coef.	95% CI	P Value
Age at visit	0.07	0.06 to 0.08	<0.001	0.08	0.07 to 0.09	<0.001	0.16	0.11 to 0.22	<0.001
Genotypea			0.002			<0.001			<0.001
PKD1 nontruncating	0.22	−0.28 to 0.73	0.39	0.57	0.29 to 0.85	<0.001	0.59	0.31 to 0.88	<0.001
PKD1 truncating	0.71	0.27 to 1.15	0.002	0.83	0.58 to 1.09	<0.001	0.86	0.60 to 1.11	<0.001
Female	−0.01	−0.20 to 0.17	0.89	0.51	0.18 to 0.84	0.003	−0.03	−0.21 to 0.16	0.79
lnhtTKV0	0.61	0.43 to 0.78	<0.001	0.61	0.43 to 0.78	<0.001	1.06	0.74 to 1.37	<0.001
Genotype×age			0.24
PKD1 nontruncating	0.01	−0.00 to 0.02	0.11
PKD1 truncating	0.004	−0.01 to 0.02	0.49
Female×age				−0.02	−0.03 to −0.01	<0.001
lnhtTKV0×age							−0.01	−0.02 to −0.01	0.001

The multivariable model included all listed variables, with one interaction tested in each model. Coef. Coefficient; 95% CI, 95% confidence interval; PKD, polycystic kidney disease; lnhtTKV0, baseline log transformed height-adjusted total kidney volume.

^aReference group of genotype is PKD2 and no mutation detected.