Table 6.

Linear mixed model with interactions for slope in log height-adjusted total cyst volume

Category	Model 1			Model 2			Model 3
	Coef.	95% CI	P Value	Coef.	95% CI	P Value	Coef.	95% CI	P Value
Age at visit	0.09	0.07 to 0.10	<0.001	0.12	0.11 to 0.13	<0.001	0.21	0.13 to 0.28	<0.001
Genotypea			0.19			<0.001			<0.001
PKD1 nontruncating	0.04	−0.58 to 0.65	0.90	0.41	0.06 to 0.75	0.02	0.42	0.08 to 0.76	0.02
PKD1 truncating	0.40	−0.13 to 0.94	0.14	0.69	0.39 to 1.00	<0.001	0.71	0.40 to 1.01	<0.001
Female	0.18	−0.05 to 0.41	0.13	1.02	0.62 to 1.42	<0.001	0.17	−0.06 to 0.40	0.14
lnhtTKV0	1.30	1.0 to 1.52	<0.001	1.30	1.08 to 1.51	<0.001	1.78	1.40 to 2.15	<0.001
Genotype×age			0.31
PKD1 nontruncating	0.01	−0.00 to 0.03	0.15
PKD1 truncating	0.01	−0.01 to 0.03	0.19
Female×age				−0.03	−0.04 to −0.02	<0.001
lnhtTKV0×age							−0.02	−0.03 to −0.01	0.003

The multivariable models included all listed variables, with one interaction tested in each model. Coef. Coefficient; 95% CI, 95% confidence interval; PKD, polycystic kidney disease; lnhtTKV0, baseline log transformed height-adjusted total kidney volume.

^aReference group of genotype is PKD2 and no mutation detected.