Table 2.

Expression of metalloproteinases and tissue inhibitors, as well as T/N staging

Parameter	Value	Tumor size			P-value	Lymph node metastasis		P-value
		T2	T3	T4		N0	N1-3
MMP-2T	Mean	44.50	61.82	51.03	0.1565 A	64.10	44.90	0.0045 t
	Coefficient of variation	34.61	34.03	39.23		24.18	42.94
MMP-2S	Mean	56.61	61.80	59.35	0.2718 KW	60.41	58.83	0.8422 U
	Coefficient of variation	6.52	18.74	6.21		17.04	7.40
MMP-2 (T-S)	Mean	-12.11	0.01	-8.31	0.1799 KW	3.69	-13.93	0.0038 U
	Coefficient of variation	-129.10	83893.99	-233.17		191.63	-127.08
MMP-9T	Mean	67.16	67.29	58.22	0.0691 A	68.72	59.50	0.0168 t
	Coefficient of variation	11.66	20.35	15.47		17.42	15.16
MMP-9S	Mean	60.99	58.75	53.30	0.1896 KW	59.20	55.35	0.1719 U
	Coefficient of variation	16.01	16.64	10.22		14.26	15.45
MMP-9 (T-S)	Mean	6.16	8.54	4.92	0.6036 A	9.52	4.15	0.0817 t
	Coefficient of variation	151.83	110.54	166.30		93.46	196.30
TIMP-1T	Mean	107.20	103.35	100.73	0.2239 A	101.97	104.05	0.4905 t
	Coefficient of variation	4.31	10.66	7.16		10.07	6.59
TIMP-1S	Mean	90.19	91.20	89.59	0.8648 A	90.86	89.84	0.6940 t
	Coefficient of variation	7.15	8.63	8.45		8.86	7.52
TIMP-1 (T-S)	Mean	17.01	12.15	11.14	0.0454 A	11.11	14.22	0.1143 t
	Coefficient of variation	18.50	49.13	48.48		53.46	35.28
TIMP-2T	Mean	89.98	90.35	88.01	0.7258 A	89.26	89.27	0.9995 t
	Coefficient of variation	5.58	10.10	8.94		10.15	7.41
TIMP-2S	Mean	77.30	81.98	80.07	0.3435 A	81.27	79.13	0.4211 t
	Coefficient of variation	6.60	8.84	8.91		10.82	6.17
TIMP-2 (T-S)	Mean	12.67	8.37	7.94	0.1091 A	8.00	10.14	0.2630 t
	Coefficient of variation	27.02	71.22	65.85		42.90	62.77

N: Nodes,T: Tumor, S: Stroma , A: Analysis of variance, t: Student's t-test, KW: Kruskal-Wallis test U: Mann–Whitney U test, MMP-2: Matrix metalloproteinase-2 , MMP-9: Matrix metalloproteinase-9 , TIMP-1: Tissue inhibitor of metalloproteinase-1