Table 3.
Expression of metalloproteinases and tissue inhibitors, as well as N staging
| Lymph node metastasis | P-value | ||||
|---|---|---|---|---|---|
| N0 | N1+2 | N3 | |||
| MMP-2T | Mean | 64.10 | 46.83 | 40.72 | 0.0150 A |
| Coefficient of variation | 24.18 | 38.77 | 55.82 | ||
| MMP-2S | Mean | 60.41 | 59.17 | 58.12 | 0.8080 KW |
| Coefficient of variation | 17.04 | 7.16 | 8.49 | ||
| MMP-2 (T-S) | Mean | 3.69 | -12.33 | -17.40 | 0.0120 KW |
| Coefficient of variation | 191.63 | -140.28 | -113.39 | ||
| MMP-9T | Mean | 68.72 | 60.96 | 56.33 | 0.0403 A |
| Coefficient of variation | 17.42 | 13.14 | 19.55 | ||
| MMP-9S | Mean | 59.20 | 56.93 | 51.92 | 0.0709 KW |
| Coefficient of variation | 14.26 | 11.77 | 22.38 | ||
| MMP-9 (T-S) | Mean | 9.52 | 4.03 | 4.41 | 0.2244 A |
| Coefficient of variation | 93.46 | 232.24 | 121.07 | ||
| TIMP-1T | Mean | 101.97 | 104.66 | 102.74 | 0.7174 A |
| Coefficient of variation | 10.07 | 6.77 | 6.58 | ||
| TIMP-1S | Mean | 90.86 | 90.48 | 88.44 | 0.7935 A |
| Coefficient of variation | 8.86 | 8.60 | 4.45 | ||
| TIMP-1 (T-S) | Mean | 11.11 | 14.18 | 14.30 | 0.2932 A |
| Coefficient of variation | 53.46 | 34.37 | 40.51 | ||
| TIMP-2T | Mean | 89.26 | 91.05 | 85.39 | 0.3317 A |
| Coefficient of variation | 10.15 | 6.58 | 7.86 | ||
| TIMP-2S | Mean | 81.27 | 78.64 | 80.18 | 0.6159 A |
| Coefficient of variation | 10.82 | 6.83 | 4.79 | ||
| TIMP-2 (T-S) | Mean | 8.00 | 12.42 | 5.21 | 0.0085 A |
| Coefficient of variation | 42.90 | 43.39 | 111.16 | ||
N: Nodes, T: Tumor, S: Stroma , A: Analysis of variance, KW: Kruskal-Wallis test, MMP-2: Matrix metalloproteinase-2 MMP-9: Matrix metalloproteinase-9, TIMP-1: Tissue inhibitor of metalloproteinase-1