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. 2019 Jul 10;3:1464. Originally published 2019 May 13. [Version 2] doi: 10.12688/gatesopenres.12957.2

Figure 5. Chemical structures of the shortlisted compounds.

Figure 5.

From the 40 compounds taken through the testing cascade for repurposed pesticides, 11 are highlighted as potentially suitable for use against mosquito vectors of malaria in an insecticide treated net. Their chemical structures are presented here. Compounds are arranged by IRAC MoA class, class 4 Nicotinic acetylcholine receptor competitive modulators on the first row, class 22 Voltage-dependent sodium channel blockers on the second, and mitochondrial complex 1 electron transport inhibitors on the third. Abamectin is Class 6, a glutamate-gated chloride channel (GluCl) allosteric modulator, spinetoram is Class 5, a nicotinic acetylcholine receptor (nAChR) allosteric modulator – Site I. Oxazosulfyl is not listed by IRAC.