Fig. 6.

Survival analyses and the median patient age at diagnosis between HRLD and LRHD patients using TCGA. (A, B) There is no significant difference between the HRLD and LRHD subtypes for either overall survival (A) or progression-free survival (B). (C) Differential impact of age on HRLD versus LRHD subtypes in the dataset of TCGA. Analyses of TCGA GBM dataset indicates that there is a significant difference in median patient age between HRLD and LRHD subtypes, but not between HR and LR subtypes. (D) The difference in the median patient age between HRLD and LRHD subtypes appears to be due to the presence of IDH mutants in the LRHD group. There is no significant difference in the median age between the LRHD and HRLD patients when IDH mutants are excluded.