Fig. 5.
Longitudinal DWI in brain of mice bearing infiltrative glioma. (A) ADC0, kurtosis, and S-index mapping determined by a non-Gaussian diffusion model on echo-planar imaging at different points. (B) Comparison of ipsilateral versus contralateral ADC0, kurtosis, or S-index values at 5, 7, and 9 weeks. Significantly increased ipsilateral kurtosis (5, 7, and 9 wk) and S-index (9 wk) are observed compared with contralateral values (**P < 0.01, ***P < 0.001, and ****P < 0.001), whereas no significant differences were observed for ADC0. Considering the ipsilateral region only, S-index and kurtosis are also significantly higher at 9 compared with 5 (##P < 0.01 and ####P < 0.0001) and 7 weeks of tumor growth ($$P < 0.01, kurtosis only).