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Electrophile-fragment library adheres to the “rule-of-three”. Distribution of (A) chloroacetamides and acrylamides in the library (B) molecular weights of the fragments, including the electrophile moiety, (C) number of heavy atoms, (D) c log P values, (E) number of rotatable bonds, (F) number of hydrogen-bond acceptors, and (G) number of hydrogen-bond donors. The library largely adheres to the “rule of three” for fragment libraries.
