Figure 5.

Proteomic Analysis of Hepatic Progenitor Stage Cells from WT and HNF4α Genome-Edited Pluripotent Stem Cells

(A) Principal component analysis of the WT, DBD Mut, and SUMO Mut cells at hepatic progenitor stage (n = 4 replicates).

(B) Top five enriched biological processes of the significantly down-regulated proteins specifically in the DBD Mut cells and the representative down-regulated mitochondrial proteins in the DBD Mut cells. Pathway enrichment was analyzed using Enrichr server.

(C) Top five enriched biological processes and the protein-protein interaction networks of the significantly down- or up-regulated proteins in the SUMO Mut cells compared with the WT. Pathway enrichment was analyzed using Enrichr server. The protein-protein interaction networks were generated on STRING server. Network nodes represent proteins, and edges represent protein-protein associations. The bolder the edge, the higher the confidence.