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. 2019 May 9;104(6):1040–1059. doi: 10.1016/j.ajhg.2019.03.024

Figure 4.

Figure 4

Gene Ontology Analysis of Deregulated RNAs in Cells Carrying HNRNPR Variants

(A) A multidimensional scaling (MDS) plot of RNA-seq samples showing the duplicate fibroblast samples in very close proximity.

(B) The top ten gene ontology (GO) terms enriched in RNAs that are upregulated in fibroblasts with HNRNPR variants compared to fibroblasts from healthy controls (using adjusted p values < 0.05).

(C) The top ten GO terms enriched in RNAs that are downregulated in fibroblasts with HNRNPR variants compared to fibroblasts from healthy controls (using adjusted p values < 0.05).

(D) All of the enriched InterPro terms from the analysis of both up- and downregulated RNAs in the fibroblasts carrying HNRNPR variants compared to fibroblasts from healthy controls.