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. 2019 May 9;104(6):1040–1059. doi: 10.1016/j.ajhg.2019.03.024

Figure 5.

Figure 5

RNA-Seq Results Reveal the Deregulation of Many RNAs Coding for Homeobox Proteins in Cells Carrying HNRNPR Variants

(A) A volcano plot of RNA-seq results showing deregulated RNAs in fibroblasts carrying HNRNPR variants compared to fibroblasts from healthy controls, using a cut-off of an adjusted p value < 0.05. Downregulated RNAs are plotted in blue, and upregulated RNAs are plotted in yellow. Downregulated RNAs coding for homeobox proteins and those found in the GO enrichment term “gonad development” are boxed in blue, and upregulated RNAs coding for homeobox proteins and those found in the GO enrichment term “embryonic skeletal system morphogenesis” are boxed in yellow.

(B) Graphs depicting the RNA-seq counts per million (CPM) of each individual RNA boxed in (A). Blue bars represent the data from the healthy controls, and beige bars represent the data from the individuals carrying variants in HNRNPR.