Figure 6.

Sashimi Plots of RNA-Seq Data Reveal Deregulation of HOX Genes and LHX9

(A) A sashimi plot focused on HOXA5 (3′ to 5′) and measuring RNA-seq reads by reads per kilobase million (RPKM) (note: not to scale). Red boxes indicate splice junctions found in both healthy control cell lines (top two panels, in black and gray) that are absent in the cells carrying HNRNPR variants (bottom panels, very dark red and fuchsia). The 3′ UTR of HOXA5 is illustrated in blue.

(B) Sashimi plots focused on a portion of the HOXB cluster. The annotated intronic HOXB3 sequence is boxed in blue.

(C) A sashimi plot focused on LHX9 (5′ to 3′).