Table 2.
Significantly (Adjusted P Value < 0.05) Upregulated RNAs Comparing Fibroblasts Carrying HNRNPR Variants (from P1 and P2) to Healthy Control Cells
| Upregulated RNAs in P1 and P2’s Cells Versus Healthy Control Cells | |||||
|---|---|---|---|---|---|
| HGNC Symbol | Ensembl Gene ID | Entrez Gene | Description | Adjusted P Value | Log2 FC |
| GSTM1 | ENSG00000134184 | 2944 | glutathione S-transferase mu 1 | 9.25 × 10−4 | 8.84 |
| PSG4 | ENSG00000243137 | 5672 | pregnancy specific beta-1-glycoprotein 4 | 1.33 × 10−2 | 7.68 |
| ADAMTS16 | ENSG00000145536 | 170690 | ADAM metallopeptidase with thrombospondin type 1 motif 16 | 1.17 × 10−2 | 5.21 |
| NA | ENSG00000234156 | NA | Antisense of OR1B1 | 2.92 × 10−2 | 4.72 |
| MIR503 | ENSG00000208005 | 574506 | microRNA 503 | 2.24 × 10−2 | 4.69 |
| FOXG1 | ENSG00000176165 | 2290 | forkhead box G1 | 8.46 × 10−3 | 4.26 |
| NA | ENSG00000282556 | NA | LincRNA | 8.68E × 10−3 | 4.24 |
| GMNC | ENSG00000205835 | 647309 | geminin coiled-coil domain containing | 4.09 × 10−2 | 4.18 |
| RGPD2 | ENSG00000185304 | 729857 | RANBP2-like and GRIP domain containing 2 | 5.25 × 10−3 | 3.93 |
| TBX1 | ENSG00000184058 | 6899 | T-box 1 | 3.53 × 10−2 | 3.93 |
| GNG4 | ENSG00000168243 | 2786 | G protein subunit gamma 4 | 3.61 × 10−2 | 3.90 |
| PLPPR5 | ENSG00000117598 | 163404 | phospholipid phosphatase related 5 | 3.32 × 10−2 | 3.59 |
| SNORD31B | ENSG00000201847 | 1E+08 | small nucleolar RNA, C/D box 31B | 4.90 × 10−2 | 3.58 |
| RPL34P19 | ENSG00000230240 | NA | ribosomal protein L34 pseudogene 19 | 3.96 × 10−2 | 3.51 |
| NA | ENSG00000257178 | NA | Intronic sense RNA HOXB3 | 3.53 × 10−2 | 3.50 |
| DPYSL4 | ENSG00000151640 | 10570 | dihydropyrimidinase like 4 | 7.79 × 10−3 | 2.68 |
| C3 | ENSG00000125730 | 718 | complement C3 | 4.40 × 10−2 | 2.51 |
| TOR4A | ENSG00000198113 | 54863 | torsin family 4 member A | 4.44 × 10−2 | 2.24 |
| CFD | ENSG00000197766 | 1675 | complement factor D | 8.46 × 10−3 | 2.20 |
| HOXB5 | ENSG00000120075 | 3215 | homeobox B5 | 8.68 × 10−3 | 2.15 |
| SPON2 | ENSG00000159674 | 10417 | spondin 2 | 3.61 × 10−2 | 2.10 |
| PLAU | ENSG00000122861 | 5328 | plasminogen activator, urokinase | 1.22 × 10−3 | 2.09 |
| PI4KAP1 | ENSG00000274602 | 728233 | phosphatidylinositol 4-kinase alpha pseudogene 1 | 1.15 × 10−2 | 2.01 |
| HOXA5 | ENSG00000106004 | 3202 | homeobox A5 | 1.17 × 10−2 | 1.92 |
| SGIP1 | ENSG00000118473 | 84251 | SH3 domain GRB2 like endophilin interacting protein 1 | 4.54 × 10−3 | 1.84 |
| PCBP3 | ENSG00000183570 | 54039 | poly(rC) binding protein 3 | 2.36 × 10−2 | 1.78 |
| COL18A1 | ENSG00000182871 | 80781 | collagen type XVIII alpha 1 chain | 3.96 × 10−2 | 1.78 |
| BMS1P2 | ENSG00000251079 | NA | BMS1, ribosome biogenesis factor pseudogene 2 | 4.40 × 10−2 | 1.69 |
| STEAP3 | ENSG00000115107 | 55240 | STEAP3 metalloreductase | 3.18 × 10−4 | 1.67 |
| IGF2BP3 | ENSG00000136231 | 10643 | insulin like growth factor 2 mRNA binding protein 3 | 3.52 × 10−3 | 1.60 |
| B3GNT5 | ENSG00000176597 | 84002 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 | 4.22 × 10−2 | 1.57 |
| MIR503HG | ENSG00000223749 | 84848 | MIR503 host gene | 1.17 × 10−2 | 1.46 |
| GFOD1 | ENSG00000145990 | 54438 | glucose-fructose oxidoreductase domain containing 1 | 7.79 × 10−3 | 1.13 |
| HOXB4 | ENSG00000182742 | 3214 | homeobox B4 | 3.48 × 10−2 | 1.13 |
| TBKBP1 | ENSG00000198933 | 9755 | TBK1 binding protein 1 | 3.49 × 10−2 | 1.10 |
| AGAP9 | ENSG00000204172 | 642517 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 9 | 2.24 × 10−2 | 1.05 |
| SLFN12 | ENSG00000172123 | 55106 | schlafen family member 12 | 4.90 × 10−2 | 0.81 |
| PLXNB1 | ENSG00000164050 | 5364 | plexin B1 | 3.96 × 10−2 | 0.80 |
| SRGAP1 | ENSG00000196935 | 57522 | SLIT-ROBO Rho GTPase activating protein 1 | 3.48 × 10−2 | 0.58 |
| SASH1 | ENSG00000111961 | 23328 | SAM and SH3 domain containing 1 | 3.61 × 10−2 | 0.44 |