Table 3.
Significantly (Adjusted P Value < 0.05) Downregulated RNAs Comparing Fibroblasts Carrying HNRNPR Variants (from P1 and P2) to Healthy Control Cells
| Downregulated RNAs in P1 and P2’s Cells Versus Healthy Control Cells | |||||
|---|---|---|---|---|---|
| HGNC Symbol | Ensembl Gene ID | Entrez Gene | Description | Adjusted P Value | Log2 FC |
| LHX9 | ENSG00000143355 | 56956 | LIM homeobox 9 | 1.00 × 10−2 | −7.51 |
| RPSAP47 | ENSG00000188856 | NA | ribosomal protein SA pseudogene 47 | 3.52 × 10−3 | −6.88 |
| DGKB | ENSG00000136267 | 1607 | diacylglycerol kinase beta | 8.68 × 10−3 | −5.78 |
| LYPD6B | ENSG00000150556 | 130576 | LY6/PLAUR domain containing 6B | 1.02 × 10−2 | −5.45 |
| NA | ENSG00000261573 | NA | Antisense of PTPRC | 2.49 × 10−2 | −5.32 |
| CLEC2A | ENSG00000188393 | 387836 | C-type lectin domain family 2 member A | 2.24 × 10−2 | −5.24 |
| ANKRD30B | ENSG00000180777 | 374860 | ankyrin repeat domain 30B | 3.85 × 10−2 | −4.37 |
| KRTAP4-9 | ENSG00000212722 | 100132386 | keratin associated protein 4-9 | 3.85 × 10−2 | −3.99 |
| PAX9 | ENSG00000198807 | 5083 | paired box 9 | 3.96 × 10−2 | −3.93 |
| NA | ENSG00000268747 | NA | Processed pseudogene | 8.46 × 10−3 | −3.77 |
| RPSAP15 | ENSG00000237506 | NA | ribosomal protein SA pseudogene 15 | 4.54 × 10−3 | −3.35 |
| RCN1P2 | ENSG00000214455 | NA | reticulocalbin 1 pseudogene 2 | 8.63 × 10−3 | −3.24 |
| PREX2 | ENSG00000046889 | 80243 | phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2 | 2.42 × 10−3 | −3.01 |
| LYPD6 | ENSG00000187123 | 130574 | LY6/PLAUR domain containing 6 | 1.40 × 10−2 | −2.98 |
| ZIC1 | ENSG00000152977 | 7545 | Zic family member 1 | 4.64 × 10−3 | −2.90 |
| KIT | ENSG00000157404 | 3815 | KIT proto-oncogene receptor tyrosine kinase | 3.96 × 10−2 | −2.71 |
| ZIC4 | ENSG00000174963 | 84107 | Zic family member 4 | 3.88 × 10−2 | −2.68 |
| MEX3B | ENSG00000183496 | 84206 | mex-3 RNA binding family member B | 3.76 × 10−2 | −2.22 |
| ZFPM2 | ENSG00000169946 | 23414 | zinc finger protein, FOG family member 2 | 5.75 × 10−3 | −2.07 |
| CPS1 | ENSG00000021826 | 1373 | carbamoyl-phosphate synthase 1 | 1.17 × 10−2 | −1.70 |
| MRPL23 | ENSG00000214026 | 6150 | mitochondrial ribosomal protein L23 | 3.96 × 10−2 | −1.61 |
| PLK2 | ENSG00000145632 | 10769 | polo like kinase 2 | 3.85 × 10−2 | −1.55 |
| SGCD | ENSG00000170624 | 6444 | sarcoglycan delta | 4.73 × 10−4 | −1.53 |
| C5orf30 | ENSG00000181751 | 90355 | chromosome 5 open reading frame 30 | 1.33 × 10−2 | −1.38 |
| SORT1 | ENSG00000134243 | 6272 | sortilin 1 | 2.92 × 10−2 | −1.19 |
| ITGA4 | ENSG00000115232 | 3676 | integrin subunit alpha 4 | 3.85 × 10−2 | −1.12 |
| RPSAP58 | ENSG00000225178 | NA | ribosomal protein SA pseudogene 58 | 3.96 × 10−2 | −1.06 |
| IRX3 | ENSG00000177508 | 79191 | iroquois homeobox 3 | 3.85 × 10−2 | −1.05 |
| CTSC | ENSG00000109861 | 1075 | cathepsin C | 3.53 × 10−2 | −1.01 |
| FNDC10 | ENSG00000228594 | 643988 | fibronectin type III domain containing 10 | 3.96 × 10−2 | −1.00 |
| FBLN7 | ENSG00000144152 | 129804 | fibulin 7 | 3.95 × 10−2 | −0.95 |
| DIXDC1 | ENSG00000150764 | 85458 | DIX domain containing 1 | 2.24 × 10−2 | −0.65 |