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. Author manuscript; available in PMC: 2019 Dec 1.
Published in final edited form as: Biomaterials. 2018 Sep 14;185:174–193. doi: 10.1016/j.biomaterials.2018.09.018

Fig.6. Effect of ultra-small particle size on theranostic particle biodistribution determined by SPECT/CT.

Fig.6.

In vivo biodistribution of ultra-small lipid coated 177LuEuCF particles (~74 MBq) was assessed in mice by SPECT/CT. (A) Experimental timeline for 177LuEuCF particles biodistribution study. (B) Representative images of 3D SPECT/CT acquisitions of whole body at 6, 24, 48, and 120 hours post-injection at a CT magnification of 2.0 and a SPECT/CT gamma camera radius of rotation (ROR) of 48 mm. Representative images of SPECT/CT acquisitions of only the chest at a higher CT magnification of 3.5 and a gamma camera ROR of 30 mm are shown. Notable is the movement of particles from the initial lung reservoir into the spleen and then liver over time. (C) Left: 3D quantification of SPECT signal using VivoQuant software displayed in counts/mm3. Right: Ex vivo radioactivity biodistribution by gamma counting analyzed by a gamma scintillation spectrometry, NaI (TI) well detector.