Table.1.
Design of multimodal theranostic nanoparticle tests in animals to predict real time drug biodistribtion.
| Groups | Formulations | Multimodal test | ||||||
|---|---|---|---|---|---|---|---|---|
| MRI | SEPCT/CT | Radioactivity | UPLC-MS/MS | ICP-MS | ||||
| Dose (mg/kg) | Time | |||||||
| RPV | Iron | Days | Hours | Days | Days | Days | ||
| G1 | NRPV | 45 | -- | -- | -- | -- | 1,2,3,5,7,1,14,21,28 | 1,2,3,5,7,1,14,21,28 |
| G2 | NRPV | 5 | -- | -- | -- | -- | 1,2,3,5,7,1,14,21,28 | 1,2,3,5,7,1,14,21,28 |
| G3 | EuCF-PCL | 2 | 2 | -- | -- | -- | 2, 5 | 2,5 |
| G4 | EuCF-PRV | 2 | 2 | 2, 5 | -- | -- | 2, 5 | 2,5 |
| G5 | EuCF-PCL + NRPV | 45 | 2 | 2, 5 | -- | -- | -- | -- |
| G6 | EuCF-PCL + NRPV | 5 | 2 | -- | -- | -- | -- | -- |
| G7 | 111lnEuCF-PCL | 600 uCi | -- | -- | 4, 12, 24, 48, 120 | 2, 5 | -- | -- |
| G8 | 177LuEuCF | 2000 uCi | -- | -- | 6, 24, 48, 120 | 1, 2, 5 | -- | -- |