Table 1.

Statistical summary of the substrate data sets curated in this study

No	MEROPS ID	Protease name	Number of substrates	Number of cleavage sites	Number	MEROPS ID	Protease name	Number of substrates	Number of cleavage sites
1	A01.009	Cathepsin D	23	59	20	M16.002	Insulysin	6	50
2	C01.032	Cathepsin L	17	63	21	S01.010	Granzyme B (human-type)	410	515
3	C02.001	Calpain-1	30	61	22	S01.017	Kallikrein-related protease 5	31	59
4	C02.002	Calpain-2	17	66	23	S01.131	Elastase-2	45	133
5	C14.003	Caspase-3	251	373	24	S01.135	Granzyme A	44	57
6	C14.004	Caspase-7	48	64	25	S01.136	Granzyme B (rodent-type)	143	157
7	C14.005	Caspase-6	58	165	26	S01.139	Granzyme M	491	707
8	C14.009	Caspase-8	37	56	27	S01.233	Plasmin	42	89
9	M10.001	Matrix metallopeptidase-1	21	52	28	S01.251	Kallikrein-related peptidase 4	78	80
10	M10.002	Matrix metallopeptidase-8	23	85	29	S08.071	Furin	56	75
11	M10.003	Matrix metallopeptidase-2	35	115	30	A01.009 (mouse)	Cathepsin D	342	579
12	M10.004	Matrix metallopeptidase-9	43	290	31	A01.010 (mouse)	Cathepsin E	655	1216
13	M10.005	Matrix metallopeptidase-3	44	132	32	C14.001 (mouse)	Caspase-1	47	53
14	M10.008	Matrix metallopeptidase-7	42	142	33	S01.010	Granzyme B (human-type)	77	88
15	M10.009	Matrix metallopeptidase-12	23	178	34	S01.136	Granzyme B (rodent-type)	168	201
16	M10.013	Matrix metallopeptidase-13	23	90	35	S08.073	PCSK2 peptidase (mouse)	21	68
17	M10.014	Membrane-type matrix metallopeptidase-1	36	92	36	S08.109	KPC2-type peptidase (Caenorhabditis elegans)	34	115
18	M12.221	ADAMTS4 peptidase	13	50	37	S26.001	Signal peptidase I (Escherichiacoli)	141	141
19	M13.001	Neprilysin	19	67	38	S26.001	Signal peptidase I (Salmonella typhimurium)	54	54