Table 2.

Intervention Sub-domains and Concepts

Sub-domains	Concepts
Genomics-informed intervention components	type: of genetic & genomic testing, sequencing purpose: to evaluate/inform risk assessment, diagnosis, therapy disclosure of results: how and by whom education: of individuals receiving care, families, clinicians
Intervention characteristics	cost, evidence, complexity
Laboratory quality and processes	technical attributes, bioinformatics pipelines, variant interpretation processes
Genomic findings	pathogenicity, actionability, diagnostic yield