TABLE 2.
Summary of synovial fluid cytology, clinical chemistry and growth factor concentrations for control and osteoarthritis group (mean ±SD).
Day | NCC (cells/μL) | Neutrophils (%) | TP (g/L) | SAA (mg/L) | PDGF-BB (pg/mL) | TGF-β1 (pg/mL) |
---|---|---|---|---|---|---|
Day 0 | ||||||
Control | 111.60 ± 39.89 | 1.60 ± 2.45 | 15.48 ± 6.31 | 0.00 ± 0.00 | - | - |
OA | 87.40 ± 53.64 | 5.40 ± 8.50 | 14.22 ± 2.56 | 0.00 ± 0.00 | - | - |
Day 1 | ||||||
Control | 22940.00 ± 11103.28*,*** | 83.40 ± 2.70*,**** | 46.64 ± 11.11* | 0.00 ± 0.00 | 390.47 ± 82.15**,*** | 4021.27 ± 783.00**,***,**** |
OA | 20464.00 ± 12055.93*,*** | 71.20 ± 5.40*,**** | 39.06 ± 7.10* | 0.00 ± 0.00 | 302.27 ± 47.44** | 2792.48 ± 615.46**,***,**** |
Day 2 | ||||||
Control | 13212.00 ± 3413.46* | 64.00 ± 4.00*,** | 30.18 ± 11.55* | 0.00 ± 0.00 | - | - |
OA | 7372.00 ± 6122.10 | 38.80 ± 14.32*,** | 22.46 ± 5.90* | 0.00 ± 0.00 | - | - |
Day 5 | ||||||
Control | 3654.00 ± 2037.59*** | 14.80 ± 11.86**** | 20.56 ± 8.02 | 0.95 ± 2.14 | 316.42 ± 45.69*** | 851.73 ± 351.82***,**** |
OA | 1660.40 ± 1250.72*** | 8.20 ± 15.54**** | 16.54 ± 6.09 | 0.00 ± 0.00 | 318.06 ± 37.82 | 678.35 ± 289.58***,**** |
Day 21 | ||||||
Control | 207.60 ± 49.90 | 2.60 ± 1.67 | 17.14 ± 6.61 | 0.00 ± 0.00 | - | - |
OA | 213.00 ± 123.80 | 5.20 ± 6.97 | 12.18 ± 3.18 | 0.00 ± 0.00 | - | - |
Day 56 | ||||||
Control | 224.80 ± 71.94 | 10.80 ± 11.16 | 14.62 ± 4.51 | 0.00 ± 0.00 | - | - |
OA | 95.60 ± 71.40 | 4.20 ± 6.79 | 13.78 ± 3.26 | 0.00 ± 0.00 | - | - |
OA, Osteoarthritis; NCC, nucleated cell count; TP, total protein; SAA, Serum amyloid A; PDGF, platelet-derived growth factor; TGF-b1, transforming growth factor-beta 1.
, Statistically significant differences from baseline, within a given group (p < 0.05).
, Statistically significant differences between groups on a specific day (p < 0.05).
, Statistically significant correlation between NCC (cells/μL) and PDGF-BB/TGF-b1 (p < 0.05).
, Statistically significant correlation between Neutrophils (%) and PDGF-BB/TGF-b1 (p < 0.05).