Fig. 4.

The TERT^high-specific miR-17-92 cluster is associated with telomere shortening. a Correlations between the PC1s of expression levels of TERT^high/TERT^low-specific miRNAs and TERT^high/TERT^low-specific mRNAs that are predicted targets. Pearson correlation coefficients (R) and P values are shown. b Box plots show higher expression levels of the miR-17-92 cluster in TERT^high patients compared to TERT^low patients. miR-17-92 cluster expression is defined as the mean of the expression of miRNAs in this cluster. The expression value is represented as log2 transformed (RSEM+ 1). P values between two groups are shown, which were calculated by the Wilcoxon rank sum test. c Correlation plots show a negative correlation between matching tumor/normal telomere length ratios and expression of the miR-17-92 cluster. Pearson correlation coefficient R and P values are shown. d Network of the miR-17-92 cluster, its target mRNAs and enriched biological processes for target mRNAs