. 2019 Jun 7;14(6):e0218110. doi: 10.1371/journal.pone.0218110

Table 1. Effect of PDE3 and PDE4 inhibition on -(dP/dt)_max.

	Saline-treated, mmHg/s (n)	PTX-treated, mmHg/s (n)
WT	-1491±467 (8)	890±534 (11)^a
AC5KO	-1686±698 (7)	844±576 (7)^a
AC6KO	-2488±357 (9)	-1656±439 (9)^b

Shown are the differences (mean±SEM) between the -(dP/dt)_max recorded after timolol and after subsequent cilostamide and rolipram (Cil/Rol). Note that in PTX-treated mice, Cil/Rol increased the -(dP/dt)_max after timolol in WT and AC5KO but decreased it in AC6KO. In contrast, Cil/Rol decreased the -(dP/dt)_max in all groups that were saline-treated. Data are given in mmHg/s (mean±SEM).

^a P<0.05 Saline vs PTX in respective group, two-way ANOVA with Tukey’s multiple comparisons test;

^b P<0.05 AC6KO PTX vs WT PTX and AC5KO PTX, two-way ANOVA with Tukey’s multiple comparisons test.

Table 1. Effect of PDE3 and PDE4 inhibition on -(dP/dt)max.

Table 1. Effect of PDE3 and PDE4 inhibition on -(dP/dt)_max.