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Mechanisms of the SLIT/ROBO pathway in tumor angiogenesis. SLIT2 and SLIT3 lead to bidirectional adjusting of angiogenesis. Through modulating the activity of ROBO1, ROBO2, ROBO4, Src, and vascular endothelial growth factor (VEGF) pathway, endothelial cell behaviors, including tube formation and filopodia formation, could be regulated.
