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. 2019 Jun 6;11:1758835919855238. doi: 10.1177/1758835919855238

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© The Author(s), 2019

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 5. — Mechanisms of the SLIT/ROBO pathway in tumor inflammation process. SLIT2 is involved in inflammation modulated by ROBO1, ROBO4, and AKT pathway. The downstream pathways of ROBO1 and ROBO4 including PI3K and nuclear factor (NF)-kB pathways involve in chemotaxis of inflammatory cells (T cells, Langerhans cells, neutrophils, and eosinophils) and angio-associated components (endothelial cells, platelets). SLIT3 regulates CXCL12/CXCR4 and RhoA in modulating inflammation, chiefly monitoring inflammatory migration and chemotaxis.