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. 2019 Sep;14(9):1573–1582. doi: 10.4103/1673-5374.255972

Figure 6.

Figure 6

Polydatin inhibits p38 MAPK signaling and the mitochondrial apoptotic pathway post-TBI.

(A) Western blot assay of p-p38, p38, cleaved caspase-9 and -3. (B) Relative band densities of p-p38 protein: The densities of the protein bands were analyzed and normalized to p38. (C, D) Relative band densities of cleaved caspase-9 and -3 proteins, respectively: The densities of the protein bands were analyzed and normalized to GAPDH. Data are expressed as the mean ± SD (n = 6; one-way analysis of variance followed by Tukey’s multiple-comparisons test). *P < 0.05, vs. sham group; #P < 0.05, vs. TBI group. PD: Polydatin; TBI: traumatic brain injury; p38 MAPK: p38 mitogen activated protein kinase; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; SRT1720: SIRT1 activator.