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. 2019 Sep;14(9):1573–1582. doi: 10.4103/1673-5374.255972

Figure 7.

Figure 7

Polydatin inhibits the endoplasmic reticulum stress response post-TBI.

(A) Western blot assay of p-PERK, PERK, spliced XBP-1, cleaved ATF6, and GRP78. (B) Relative band densities of p-PERK protein: The densities of the protein bands were analyzed and normalized to PERK. (C–E) Relative band densities of spliced XBP-1, spliced cleaved ATF6 and GRP78 proteins, respectively: The densities of the protein bands were analyzed and normalized to GAPDH. Data are expressed as the mean ± SD (n = 6; one-way analysis of variance followed by Tukey’s multiple-comparisons test). *P < 0.05, vs. sham group; #P < 0.05, vs. TBI group. PD: Polydatin; TBI: traumatic brain injury; p-PERK: phosphorylated protein kinase R-like endoplasmic reticulum kinase; PERK: protein kinase R-like endoplasmic reticulum kinase; XBP-1: X box-binding protein-1; ATF6: activating transcription factor 6; GRP78: glucose-regulated protein 78; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; SRT1720: SIRT1 activator.