Figure 1.

Beneficial effects of sodium butyrate (SB) on radiation-induced cognitive impairment after 30 days of radiation exposure.

(A) Sham and irradiated mice treated with vehicle or sodium butyrate exhibited no differences in their preference for the two objects (cube (object A) and pyramid shape (object B)) during training in the object recognition test. (B) During the test phase, the vehicle-treated irradiation group (10 Gy group) exhibited reduced preference for a novel object (cylinder shape (object C)) compared to the vehicle-treated sham group (sham group), and injection of sodium butyrate attenuated the radiation-induced cognitive impairment. (C) The discrimination ratio was markedly lower in the 10 Gy group, and SB treatment inhibited the decrease of discrimination ratio by radiation exposure after 30 days. The data are shown as the mean ± SE (n = 10/group). *P < 0.05 (one-way analysis of variance followed by Student-Newman-Keuls post hoc test).