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. 2019 Sep;14(9):1603–1609. doi: 10.4103/1673-5374.255979

Figure 4.

Figure 4

Relative luciferase activity in sw-APP795-HEK293 cells co-transfected with pmirGLO/APP 3′-UTR WT, pmirGLO/APP 3′-UTR MT and miR-15b-5p mimics or miR-15b-5p mimics NC.

(A) Schematic diagram shows the putative biding site between miR-15b-5p and the 3′-UTR of APP, as predicted by an online tool (mirna.org). (B) Relative luciferase activity in each group. Data are expressed as the mean ± SD. *P < 0.05, vs. APP 3′-UTR WT + miR-15b-5p mimics NC (one-way analysis of variance followed by Fisher’s least significant difference test). APP: Amyloid precursor protein; UTR: untranslated region; WT: wild-type; MT: mutant; NC: normal control.