Skip to main content

View full-text article in PMC

. Author manuscript; available in PMC: 2019 Jun 10.

Published in final edited form as: Am J Obstet Gynecol. 2018 Nov 9;220(2):187.e1–187.e8. doi: 10.1016/j.ajog.2018.11.121

Table 3.

Comparisons of growth factors and collagen measurements in vaginal mesh-tissue complexes removed for mesh exposure or pain.

	Tissue type			P-values ^b
	Control	Exposure	Pain	E vs. C	P vs. C	P vs. E
T cell population	n=21	n=20	n=17
CD4⁺ Thelper	3.81 ± 5.30	52.75 ± 36.69	58.47 ± 56.02	<0.001	<0.001	0.722
foxp3⁺ Treg	3.17 ± 3.49	21.87 ± 17.18	14.62 ± 9.18	<0.001	<0.001	0.081
CD8⁺ cytotoxic	18.84 ± 27.83	37.38 ± 24.75	23.33 ± 15.04	0.034	0.520	0.032

Growth factors	n=11	n=15	n=10
TGF-β (μg/mg)	2.18 ± 1.57	4.15 ± 1.89	4.67 ± 2.06	0.008	0.004	0.540
CTGF (μg/mg)	1.88 ± 1.16	6.51 ± 3.63	4.14 ± 2.93	<0.001	0.008	0.060

Collagen	n=12	n=16	n=11
thin/thick fibers	-	3.14 ± 1.09^d	1.72 ± 0.91^d	-	-	0.005 ^c
collagen I ^a	0.91 ± 0.41	1.15 ± 0.48	1.33 ± 0.64	0.120	0.057	0.392
collagen III ^a	0.27 ± 0.18	0.28 ± 0.17	0.39 ± 0.32	0.920	0.256	0.251
III/I ratio ^a	0.19 ± 0.06	0.15 ± 0.06	0.18 ± 0.11	0.081	0.818	0.303

Values represent mean ± standard deviation

^a:

values normalized to internal controls

^b:

P-values from mixed effects linear regression

^c:

P-value from Student’s t-test

^d:

n=10; E: exposure; C: control; P: pain.