Fig. 4.

Effects of tedizolid and comparator antibiotics on S. aureus alpha-haemolysin activity. Alpha-haemolysin activity was quantified from culture supernatants by rabbit erythrocyte lysis assay. Each panel shows alpha-haemolysin activity following treatment with the indicated antibiotic in (a–c) S. aureus FPR3757 and in (d–f) MSSA 04–002. Bars represent average toxin expression±standard error from three biological replicates. Asterisks denote statistical significance of (*) P<0.05, (**) P<0.01, (***) P<0.001 and (****) P<0.0001 compared to the no treatment (NT) vehicle control at each corresponding timepoint. A hash mark (#) indicates that no toxin was detected.