Table 4.
Potential outcome measures by treatment group
| Potential outcome measures | 10 mL/kg (n=39) |
20 mL/kg (n=34) |
Difference (95% CI) |
| Hospital mortality, n/N (%) | 0/39 (0.0) | 0/34 (0.0) | NA |
| Length of hospital stay (days), median (IQR) (N) | 4 (3–7) (39) | 5 (4–8) (34) | −1 (−2.5 to 0.5) |
| Transferred to PICU, n/N (%) | 10/39 (25.6) | 11/34 (32.4) | −6.7 (−27.6 to 14.1) |
| Length of stay in PICU (hours), median (IQR) (N) | 45 (18–143) (10) | 119 (52–228) (11) | −65 (−171 to 41) |
| Days alive and free of PICU up to 30 days postrandomisation, mean (SD) (N) | 28.9 (2.4) (39) | 27.9 (3.6) (34) | 1.0 (−0.4 to 2.4) |
| Receipt of mechanical ventilation, n/N* (%) | 4/36 (11.1) | 8/32 (25.0) | −13.9 (−32.1 to 4.3) |
| Duration of mechanical ventilation (days), median (IQR) (N)* | 6 (4–8) (4) | 5.5 (4–8.5) (8) | 0 (−5.9 to 5.9) |
| Days alive and free of mechanical ventilation up to 30 days postrandomisation, mean (SD) (N)* | 29.3 (2.1) (36) | 28.5 (2.7) (32) | 0.8 (−0.4 to 2.0) |
| Receipt of inotropes, n/N* (%) | 1/36 (2.8) | 5/32 (15.6) | −12.8 (−26.5 to 0.8) |
| Mortality at 30 days postrandomisation, n/N (%) | 0/39 (0.0) | 0/34 (0.0) | NA |
*Organ support data missing for three patients in the 10 mL/kg group and two patients in the 20 mL/kg group transferred to PICUs not participating in the pilot trial.
NA, not available; PICU, paediatric intensive care unit.