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. Author manuscript; available in PMC: 2020 Jan 15.
Published in final edited form as: Bioorg Med Chem Lett. 2019 May 13;29(14):1756–1760. doi: 10.1016/j.bmcl.2019.05.017

Scheme 1.

Scheme 1

Schematic representation of the synthesis of dextran-conjugated TAM radicals using a click chemistry approach. The dextran grafting by the dFTr radical was achieved by copper-catalyzed azide-alkyne cycloaddition (CuAAC) of a TAM mono-propargyl ester followed by addition of excess of alkyne-PEG. Varying the trityl radical/dextran ratio allows for the tuning of the radical loading onto the polymer. Incorporation of PEG chains enhances the solubility of the grafted dextran and prevents spin-spin interactions between trityl radicals.