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. 2019 May 20;11(6):1586–1601. doi: 10.1093/gbe/evz102

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© The Author(s) 2019. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Fig. 2. — —Evolutionary relationships of human IGSF1 and A1BG with known LRC members. Unrooted NJ tree for nucleotide sequences encoding individual Ig-like domains is shown. Bootstrap values greater than 50% are shown at the nodes. Branch lengths depict evolutionary distance. The trees were generated using MEGA6 software with p-distances for nucleotide sequence sites and pair-wise deletion option. To reduce the size of the tree, the clusters for highly related Ig-like domains of various LILRs and KIRs were compressed and designated according to the domain subtype they represent (D1–D4 for LILRs and D0–D2 for KIRs).