Table 1 ∣.
Examples of mitotic bookmarking factors
| Bookmarking factor | System | Role (specific function) | Refs |
|---|---|---|---|
| TFIID, TFIIB and TBP | HeLa (human, cervical cancer) | General transcription factors | 13-16 |
| CTCF | HeLa (human, cervical cancer) | Insulator | 28 |
| FOXI1 | PAC2 (zebrafish, fibroblasts) | Forkhead transcription factor (development of cochlea and vestibulum) | 79 |
| RUNX2 | Saos-2 (human, osteosarcoma) | Runt transcription factor (osteoblastic differentiation and skeletal morphogenesis) | 80 |
| BRD4 | NIH3T3 (mouse, fibroblasts) | Chromatin reader | 26 |
| MLL | HeLa (human, cervical cancer) | Transcription co-activator | 24 |
| GATA1 | G1E (mouse, erythroid precursors) | Transcription factor (erythroid development) | 18 |
| FOXA1 | HUH7 (human, hepatocarcinoma) | Forkhead transcription factor (liver development) | 19 |
| RBPJ | F9 (mouse, testis) | Transcription regulator (regulation of Notch signalling pathway) | 81 |
| PARP1 | HEK293 (mouse, kidney) | Poly(ADP-ribosyl)transferase | 82-84 |
| ORC1 | U2OS (human, osteocarcinoma) | Origin of replication complex protein | 85 |
| RING1 and BMI1 | HeLa (human, cervical cancer) | Transcription repressors of the Polycomb group complex 1 | 86 |
| HNF1β | IMCD3 (mouse, kidney), MDCK (dog, kidney) and mouse kidney | POU-homeobox transcription factor (kidney and pancreas development) | 20,21 |
| ESRRβ, SOX2, OCT4 and KLF4 | Embryonic stem cells | Pluripotency transcription factors | 2,23,27,37 |
BMI1, Polycomb repressive complex; BRD4, bromodomain-containing protein 4; CTCF, CCCTC-binding factor; ESRRβ, oestrogen-related receptor-β; FOXA1, forkhead box protein A1; GATA1, GATA-binding protein 1; HNF1β, hepatocyte nuclear factor 1β; KLF4, Kruppel-like factor 4; MLL, myeloid/lymphoid or mixed-lineage leukaemia protein 1; OCT4, octamer-binding protein 4; ORC1, origin recognition complex subunit 1; PARP1, poly(ADP-ribose) polymerase 1; RBPJ, recombining binding protein suppressor of hairless; RING1, RING finger protein 1; RUNX2, Runt-related transcription factor 2; SOX2, SRY box 2; TBP, TATA-box binding protein; TFIID, transcription factor IID.